Darunavir(TMC114) is an HIV protease inhibitor.Darunavir HIV-1 antiviral structurally is similar to amprenavir and it is second generation HIV-1-protease inhibitor. Darunavir(brand name?Prezista, formerly known as TMC114) is a drug used to treat HIV infection. It is in the protease inhibitor class. Prezista is an OARAC recommended treatment option for treatment-na?ve and treatment-experienced adults and adolescents.