Product Name:Epothilone D;埃博霉素D;埃坡西龙D
Synonym:Desoxyepothilone B; KOS-862;NSC703147;dEpoB;12,13-Desoxy-Epothilone B;(-)-Desoxyepothilone B
Chemical Name:(3S,7S,14S,15S,16R)-3,15-Dihydroxy-2,2,10,14,16-pentamethyl-7-[1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-6-oxacyclohexadec-9-ene-1,5-dione
CAS No. :189453-10-9
Molecular Formula:C27H41NO5S
Molecular Weight:491.68
Characters:White powder
Purity:>98% by HPLC
Biological Activity ofEpothilone D:
A natural polyketide compound isolated from the myxobacterium Sorangium cellulosum. Also known as desoxyepothilone B, epothilone D binds to tubulin and inhibits the disassembly of microtubules, resulting in the inhibition of mitosis, cellular proliferation, and cell motility.
Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells? microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers.
(此产品仅适用于科学研究,不得用于其他目的)
