RMB:600.00/100mg
别名：替尼泊苷;4-去甲基表鬼臼毒素-beta-D-噻吩亚甲基吡喃葡萄糖甙
英文名：Teniposide/VM-26
分子式：C32H32O13S
分子量： 656.66
纯度： >99%
外观：白色粉末
CAS No： 29767-20-2
Biological Activity:
Glycoside-derivative of podophyllotoxin. Has cytostatic effect. Inhibits topoisomerase II. Induces apoptos.
Teniposide(Vumon) is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia (ALL). It is in a class of drugs known as podophyllotoxin derivatives and slows the growth of cancer cells in the body. Teniposide causes dose-dependent single- and double-stranded breaks in DNA and DNA-protein cross-links. The mechanism of action appears to be related to the inhibition of type II topoisomerase activity since teniposide does not intercalate into DNA or bind strongly to DNA.
