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MKK3 (N-term)

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MKK3 (N-term) Antibody Rabbit Monoclonal Antibody Cat.# 1728-1

MKK3 （N-term） Antibody
Rabbit Monoclonal Antibody

Cat.# 1728-1

Description

Mitogen-acitvated protein kinase kinase 3 （MKK3） belongs to the serine/threonine protein kinase family ａnd the MAPK kinase subfamily （MAP2K, MKK or MEKs）. MAPKs require dual phosphorylation on threonine ａnd tyrosine residues, an activation step carried out by MAPK kinase （1-2）. MKK3, closely related to MKK6, efficiently phosphorylates ａnd activates p38 MAP kinase in response to inflammatory cytokines ａnd environmental stress but not JNK or ERK （3）. MKK3 is activated by mitogenic ａnd environ-mental stress stimulus as well as by insulin. MKK3 is necessary for the expression of glucose transporter ａnd participates in the MAP kinase- mediated signaling cascade （4）.

Recommended Applications WB, FC, IP

Applications ａnd Recommended Dilution Factors

WB	IHC	ICC	FC	IP

1:500-20000			1:20	1:50

Species Reactivity*

Human	Mouse	Rat

Positive	Negative	Negative	*Cross reactivity determined by western blot only.

Product Data


A. Western blot analysis of MKK3 using anti-MKK3 （N-term） RabMAb （cat. # 1728-1）, dilution 1:20,000 A: Jurkat B: Hela C: MCF-7 D: K562

Specificity

A synthetic peptide corresponding to residues in the N-terminus of human MKK3 was used as immunogen.

Storage Buffer & Conditions

50 mM Tris-Glycine （pH 7.4）, 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide ａnd 0.05% BSA.

Alternative Names

MAP2K3, MEK3, MKK3, PRKMK3, Dual specificity mitogen-activated protein kinase kinase 3, MAPK/ERK kinase 3

Description References

1. Han, J.; Lee, J.-D.; Jiang, Y.; Li, Z.; Feng, L.; Ulevitch, R. J. : J. Biol. Chem. 271: 2886-2891, 1996.
2. Seger, R.; Krebs, E. G. : FASEB J. 9: 726-735, 1995.
3. Bernd Stein, Helen Brady, Maria X. Yang , David B. Young, Miguel S. Barbosa, Volume 271, Number 19, Issue of May 10, 1996 pp. 11427-11433
4. Fujishiro et al. J. Biol. Chem., Vol. 276, Issue 23, 19800-19806, 2001

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MKK3 (N-term)