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CAS No. : 142948-19-4
MCE 国际站:Scyllatoxin
产品活性:Scyllatoxin (Leiurotoxin I) 是一种肽毒素,它可以从毒蝎 (Leiurus quinquestriatus hebraeus) 的毒液中「分离出来。Scyllatoxin 是小电导钙激活型钾通道 KCa (SK) 的阻断剂。Scyllatoxin 能够增强〖体内去甲肾上腺素 (NE) 和肾上腺素 (Epi) 的释放。
研究领域:Membrane Transporter/Ion Channel
作用靶点:Potassium Channel
In Vitro: For scyllatoxin, the Arg6 and Arg13 are essential for binding to the Ca2+-activated K+ channel protein and for the functional effect of the toxin.
For scyllatoxin, His31 is important for the binding activity of the toxin and for the induction of contractions on taenia coli.
In Vivo: Scyllatoxin (2 μM) increases basal Epi release, the nerve stimulation-induced Epi release and the exogenous acetylcholine (Ach)-induced catecholamine release by microdialysis technique to the left adrenal medulla of anesthetized adult male Wistar rats.
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