NANOPHOX/R
Particle size & stability analysis
with Photon Cross-correlation Spectroscopy from 0.5 nm to 10 µm
NANOPHOX/G is an innovative Photon Cross-correlation sensor allowing for simultaneous measurement
of particle size and stability of opaque emulsions and suspensions in the nanometer regime.
Technical specificationsanddimensions.
Photon Cross‐correlation Spectroscopy (PCCS) | Particle Size and Stability with NANOPHOX/R from 0.5 nm to 10,000 nm
In general, the acquisition of scattered light intensities of particles under thermal motion is deployed for nanoparticle characterisation (principle of dynamic light scattering (DLS)). The method known as Photon Correlation Spectroscopy (PCS) applies auto‐correlation of scattered light intensities in order to determine particle size distribution. However, this conventional technology requires extremely diluted samples in order to deliver meaningful results.
NANOPHOX/R brings Photon Cross‐correlation Spectroscopy (PCCS) to life, which allows for nanoparticle size analysis in turbid suspensions and emulsions ranging from 0.5 nm to 10,000 nm at up to a hundred times higher solid contents. In addition, stability of nanosuspensions and emulsion may be analysed. The outstanding technological feature of NANOPHOX is the acquisition of two separately induced scattered light intensities which then are cross‐correlated. This allows for robust measurement even at higher sample concentrations. Typical applications comprise e.g., pharmaceutical ingredients, pigments and research on nanomaterials in general.
| Sensor | NANOPHOX/R |
| Overall measuring range | 0.5 - 10,000 nm |
|
Measuring Principle |
Dynamic light scattering (DLS), at 90° Photon cross-correlation Spectroscopy (PCCS) |
| Light Source | λ = 658 nm (red), Pout= 0 - 35 mW, adjustable1 |
| Protection class | 1 |
| Optics | two optical paths via beam splitter, alignment free |
| Measuring zone |
temperature controlled water basin, free of condensation, vial holder on adjustable X/Y-table2 |
| Temperature range | 1 - 90°C typ. |
| Temperature stability | ± 0.1°C |
| Temperature accuracy | ± 0.1°C at 20°C, direct measurement at the vial |
| Sample vials | disposable micro vials 50 µl to 2 ml |
| disposable micro vials 4 ml | |
| glass vials (crown glass) up to 4 ml | |
| Evaluation | software WINDOX, ≥ release 5.8.1 |
| Auto NNLS | non -negative least square analysis with system- |
| defined input values, automatic fit range | |
| NNLS | user defined fit-range optimisation for fine tuning |
| e.g. of PSDs with multiple modes | |
| 2nd Cumulant | second cumulant approximation (mean & width) |
| Stability analysis3 | cross-correlation amplitude as stability measure |
| Compliance | FDA 21 CFR Part 11, ISO 22412 |
