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MCE 国际站:Cecropin P1, porcine acetate
产品活性:Cecropin P1, porcine acetate 是一种抗菌 (antibacterial) 肽,可从猪小肠上部分离。Cecropin P1, porcine acetate 对革兰氏阴性菌具有抗菌活㊣ 性。Cecropin P1, porcine acetate 具有抗病毒 (antiviral) 活性,可抑制 PRRSV 感染。
研究领域:Anti-infection | Metabolic Enzyme/Protease
作用靶点:Bacterial | Endogenous Metabolite
In Vitro: Cecropin P1, porcine (0-480 μg/mL, 36-96 h) markedly inhibits CH-1a infection and replication in Marc-145 cells.
Cecropin P1, porcine (0-480 μg/mL, 36 h) not only displays extracellular virucidal activity against PRRSV (porcine reproductive and respiratory syndrome virus), but also exerts a potent inhibitory effect when added either before, simultaneously with, or after viral inoculation.
Cecropin P1, porcine (480 μg/mL, 0-72 h) blocks CH-1a-induced apoptosis during the late phase of infection.
Cecropin P1, porcine (0-480 μg/mL, 0-4 h) inhibits viral particle release.
In Vivo: Cecropin P1 (1 mg/kg, IP, once) prevents bacterial growth, endotoxemia, and mortality in rats with septic shock.
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