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CAS No. : 2387510-88-3
MCE 国际站：OD36 hydrochloride
产品活性：OD36 hydrochloride 是一种 RIPK2 抑制剂，IC50 为 5.3 nM。OD36 hydrochloride 是一种大环抑制剂，可与 ALK2 激酶 ATP 口袋有效结合。OD36 hydrochloride 靶向作用于 ALK2，KD 为 37 nM。
研究领域：Apoptosis | TGF-beta/Smad
作用靶点：RIP kinase | TGF-β Receptor
In Vitro: OD36 also inhibits ALK2 and ALK2 R206H with IC50s of 47 and 22 nM, respevtively.
OD36 shows activity against ALK1 with a KD of 90 nM.
OD36 potently antagonize mutant ALK2 signaling and osteogenic differentiation.
OD36 (0.1-1 μM; 24 h) efficiently inhibits BMP-6 (50 ng/mL)-induced p-Smad1/5 in KS483 cells.
Preincubation of fibrodysplasia ossificans progressiva (FOP) endothelial colony-forming cells (ECFCs) with OD36 (0.5 μM) completely prevents the activation of Smad1/5 and gene targets ID-1 and ID-3 in response to activin A.
In Vivo: OD36 (6.25 mg/kg; i.p.; once) alleviates inflammation in an acute peritonitis mice model.
相关产品：LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA) | ML347 | RIPA-56 | Zilurgisertib | RIPK1-IN-3 | RIP1 kinase inhibitor 1 | TGFβRI-IN-3 | Vactosertib | Itacnosertib | RIP2 kinase inhibitor 2 | PROTAC RIPK degrader-6 | PK68 | RIPK1-IN-4 | Maohuoside A | RIPK1-IN-14 | SB-505124 hydrochloride | K02288 | J-1063 | ALK5-IN-25 | GSK963 | LY-364947 | AV123 | TP-008 | RIP2 Kinase Inhibitor 4 | ALK2-IN-4 | Necrostatin 2 | RIPK1-IN-11 | Galunisertib | CJJ300 | ALK5-IN-7
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Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
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