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CAS No. : 125313-92-0
MCE 国际站：MKC-1
产品活性：MKC-1 (Ro-31-7453) 是一种口服有效的细胞周期抑制剂，具有㊣广泛的抗肿瘤活性。MKC-1 抑制 Akt/mTOR 通路。通过结合一系列不同的细胞蛋白，包◢括微管蛋白 (tubulin) 和导入蛋白 β (importin β) 家族成员，MKC-1 阻止细胞有丝分裂并诱导细胞凋亡 (apoptosis)。
研究领域：PI3K/Akt/mTOR | Cytoskeleton | Cell Cycle/DNA Damage | Apoptosis
作用靶点：Akt | mTOR | Microtubule/Tubulin | Apoptosis
In Vivo: MKC-1 (200 mg/kg, orally, daily) significantly increased the median survival time (MST) of mice bearing Caki-1 renal cell xenograft tumors.
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