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                MP 原装现货 DSS硫酸葡♂聚糖100g

                MP 原装现货 DSS硫酸葡聚糖100g
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                • MP 原装现货 DSS硫酸葡聚糖100g
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                产品报价: 2800
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                MP
                0216011080
                高教 职教
                广东 广州
                南方医科大学,暨南大学,广州中医药¤大学,中山大学,广东医科大学
                详细说明

                MP 原装现货 DSS硫酸葡聚糖100g

                DSS-最有效的肠炎造模试剂

                葡聚糖硫酸钠(DSS)是葡聚糖的聚阴离子衍生物。我们的DSS因为其具有最高质量,纯度和可重复性,使其应用于很多领域,包括:临床,分子生物学,生物医学甚至化妆品领域.
                葡聚糖硫酸钠具有如下特性:
                炎性肠病(IBD)的特征是慢性、复发性胃肠道炎症,其可增加患结肠炎相关性癌症的风险。已经有几种动物模型被用于研究肠炎,其中一个模型就是通过小鼠口服葡聚糖硫酸钠(DSS)的水溶液来诱导慢性肠炎。DSS诱导的肠炎模型是自发的,并且可←以用来评估IBD的治疗潜力.
                使用最有效的葡聚糖硫酸钠可以加速您的IBD研究。我们的DSS具有以下优势→:
                最好的结果!
                Bamba等人(2012)对3种不同的DSS进行了比较分析,研究了它们的化学性质和细胞毒性以及引发的肠炎严重性。他们的研究结论是,我们的DSS可引发一种严重的肠炎,通过体重变化,DAI评分,结肠重量/长度和组织学评分这些指标显示.

                1) Mouli, V.P., Ananthakrishnan, A.N. Review article: Vitamin D and inflammatory bowel diseases (2014) Alimentary Pharmacology and Therapeutics, 39 (2), pp. 125-136.

                2) Salcedo, R., Cataisson, C., Hasan, U., Yuspa, S.H., Trinchieri, G. MyD88 and its divergent toll in carcinogenesis (2013) Trends in Immunology, 34 (8), pp. 379-389.

                3) Zindl, C.L., Lai, J.-F., Lee, Y.K., Maynard, C.L., Harbour, S.N., Ouyang, W., Chaplin, D.D., Weaver, C.T. IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis (2013) Proceedings of the National Academy of Sciences of the United States of America, 110 (31), pp. 12768-12773.

                4) Tanaka, T., Ishikawa, H. Mast cells and inflammation-associated colorectal carcinogenesis (2013) Seminars in Immunopathology, 35 (2), pp. 245-254.

                5) Tanaka, T. Development of an inflammation-associated colorectal cancer model and its application for research on carcinogenesis and chemoprevention (2012) International Journal of Inflammation, 2012, art. no. 658786.

                5) Sussman, D.A., Santaolalla, R., Strobel, S., Dheer, R., Abreu, M.T. Cancer in inflammatory bowel disease: Lessons from animal models (2012) Current Opinion in Gastroenterology, 28 (4), pp. 327-333.

                6) Perše, M., Cerar, A. Dextran sodium sulphate colitis mouse model: Traps and tricks (2012) Journal of Biomedicine and Biotechnology, 2012, art. no. 718617.

                7) Vora, P., McGovern, D.P.B. LRRK2 as a negative regulator of NFAT: Implications for the pathogenesis of inflammatory bowel disease (2012) Expert Review of Clinical Immunology, 8 (3), pp. 227-229.

                8) Zhao, W.-C., Song, L.-J., Deng, H.-Z. Protective effect of total alkaloids of sophora alopecuroides on dextran sulfate sodium-induced chronic colitis (2011) Chinese Journal of Integrative Medicine, 17 (8), pp. 616-624.

                9) Azuma, Y.-T., Nakajima, H., Takeuchi, T. IL-19 as a potential therapeutic in autoimmune and inflammatory diseases (2011) Current Pharmaceutical Design, 17 (34), pp. 3776-3780.

                10) Naito, Y., Takagi, T., Uchiyama, K., Yoshikawa, T. Heme oxygenase-1: A novel therapeutic target for gastrointestinal diseases (2011) Journal of Clinical Biochemistry and Nutrition, 48 (2), pp. 126-133.

                11) Egea, L., Hirata, Y., Kagnoff, M.F. GM-CSF: A role in immune and inflammatory reactions in the intestine (2010) Expert Review of Gastroenterology and Hepatology, 4 (6), pp. 723-731.

                12) Takagi, T., Naito, Y., Uchiyama, K., Yoshikawa, T. The role of heme oxygenase and carbon monoxide in inflammatory bowel disease (2010) Redox Report, 15 (5), pp. 193-201.

                13) Shukla, P., Gupta, G., Singodia, D., Shukla, R., Verma, A.K., Dwivedi, P., Kansal, S., Mishra, P.R. Emerging trend in nano-engineered polyelectrolyte-based surrogate carriers for delivery of bioactives (2010) Expert Opinion on Drug Delivery, 7 (9), pp. 993-1011.

                14) Solomon, L., Mansor, S., Mallon, P., Donnelly, E., Hoper, M., Loughrey, M., Kirk, S., Gardiner, K. The dextran sulphate sodium (DSS) model of colitis: An overview (2010) Comparative Clinical Pathology, 19 (3), pp. 235-239.

                15) Strauch, U.G., Grunwald, N., Obermeier, F., Gürster, S., Rath, H.C. Loss of CD103+ intestinal dendritic cells during colonic inflammation (2010) World Journal of Gastroenterology, 16 (1), pp. 21-29.

                16) Maxwell, J.R., Brown, W.A., Smith, C.L., Byrne, F.R., Viney, J.L. Methods of inducing inflammatory bowel disease in mice (2009) Current Protocols in Pharmacology, (SUPPL.47), pp. 5.58.1-5.58.37.

                17) Waldner, M.J., Neurath, M.F. Chemically induced mouse models of colitis (2009) Current Protocols in Pharmacology, (SUPPL. 46), pp. 5.55.1-5.55.15.

                18) Nishihira, J., Mitsuyama, K. Overview of the role of macrophage migration inhibitory factor (MIF) in inflammatory bowel disease (2009) Current Pharmaceutical Design, 15 (18), pp. 2104-2109.

                19) Soeda, S., Sakata, A., Ochiai, T., Yasuda, K., Kuramoto, Y., Shimeno, H., Toda, A., Eyanagi, R., Hikishima, S., Yokomastu, T., Shibuya, S. Sphingomyelinase inhibition suggests a possible new strategy for the treatment of inflammatory bowel disease (2008) Current Drug Therapy, 3 (3), pp. 218-225.

                20) Kawada, M., Arihiro, A., Mizoguchi, E. Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease (2007) World Journal of Gastroenterology, 13 (42), pp. 5581-5593.

                21) Clapper, M.L., Cooper, H.S., Chang, W.-C.L. Dextran sulfate sodium-induced colitis-associated neoplasia: A promising model for the development of chemopreventive interventions (2007) Acta Pharmacologica Sinica, 28 (9), pp. 1450-1459.

                22) Butterworth, J.R. Another important function for an old friend! The role of iron in colorectal carcinogenesis (2006) Gut, 55 (10), pp. 1384-1386.

                23) Di Pace, R.F., Massa, S., Ribeiro, O.G., Cabrera, W.H.K., De Franco, M., Starobinas, N., Seman, M., Ibañez, O.C.M. Inverse genetic predisposition to colon versus lung carcinogenesis in mouse lines selected based on acute inflammatory responsiveness (2006) Carcinogenesis, 27 (8), pp. 1517-1525.

                24) Guarner, F. Inulin and oligofructose: Impact on intestinal diseases and disorders (2005) British Journal of Nutrition, 93 (SUPP), pp. S61-S65.

                25) Dagenais, S., Haldeman, S., Wooley, J.R. Intraligamentous injection of sclerosing solutions (prolotherapy) for spinal pain: A critical review of the literature (2005) Spine Journal, 5 (3), pp. 310-328. Cited 30 times.

                26) Mirvish, S.S., Haorah, J., Zhou, L., Hartman, M., Morris, C.R., Clapper, M.L. N-Nitroso compounds in the gastrointestinal tract of rats and in the feces of mice with induced colitis or fed hot dogs or beef (2003) Carcinogenesis, 24 (3), pp. 595-603.

                温馨提示:不可用于临床治疗。

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