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FieldStere是什么?
找到最精确的,多样化的类似药物类的生物电子等排体
FieldStere帮助你优化缩短你的最适化周期,通过选择最好的合成、微调部分的铅分子和启用脚手架转换扩展到新化学空间。
FieldStere 发现生物电子等排体带领分子,这共享相同的生物活性,但有一系列不同的核心支架。FieldStere易用的界面快速生 成一系列潜在的铅分ω子，从最初的2 d结构,并帮助你〖选择最创新和易于处理的领导性能。因为FieldStere使用字段,而不是2 d结构,它可以准确地识别结构多样化的bioisosteres有或没有知识的目标蛋白质的□ 结构。
Finding the most accurate, diverse set of drug-like bioisosteres
What is FieldStere?
Finding the most accurate, diverse set of drug-like bioisosteres
FieldStere helps you shorten your lead optimization cycles by choosing the best next synthesis, fine-tuning portions of lead molecules and enabling scaffold switching to expand into new chemical space.
FieldStere finds bioisosteric lead molecules that share the same biological activity, but which have a range of different core scaffolds. FieldStere’s easy-to-use interface quickly generates a range of potential lead molecules from an initial 2D structure and helps you choose the most innovative and tractable leads with the properties you need. Because FieldStere uses Fields, not 2D structure, it can accurately identify structurally diverse bioisosteres with or without knowledge of the target protein’s structure. FieldStere helps Computational Chemists to:
Generate highly innovative ideas for lead molecules in new, areas of chemical space, overcoming the ‘chemotype trap’
Find the right results quickly using new filters to find the mix of physicochemical properties and biological activity needed
Tailor results to a specific synthesis by selecting the chemistry allowed for the replacement moieties, including a new ‘Rings Only’ option
Visualize results in detail side-by-side, or using powerful new tools to cluster similar chemical scaffolds
Ensure that suggested molecules are synthesizable
FieldStere is easy enough to use every day to optimize your leads, and powerful enough to switch scaffolds completely while retaining the desired activity and ensuring that your candidate leads are free from known IP, ADME or toxicity issues.
Changing the way we think and work with small molecules
Experience the advantage of Field based chemistry!
