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FieldScreen是最完整的搜索为多样化、创新bioisosteres。FieldScreen帮助你找到一个结构多样化的异常铅像分子，用同样的生物活性分子作为你的筛查击中或铅。FieldScreen帮助你为异常综合体提出新观点,支架之间切换当铅系列阻塞时。
FieldScreen是一个虚拟筛选系统,返回一套异常的bioisosteres，无论有或没有目标的蛋白质结构知识的。FieldScreen比较了周围的领域你的铅在一个给定的三维形态与数据库中的字段ω从几百万〗药物类化合物创建pharmacophores。
The most complete search for diverse, innovative bioisosteres
What is FieldScreen?
The most complete search for diverse, innovative bioisosteres
FieldScreen helps you to find a structurally diverse set of novel lead-like molecules with the same biological activity as your screening hit or lead. FieldScreen helps you come up with new ideas for novels syntheses, and switch between scaffolds when the lead series becomes blocked.
FieldScreen is a ligand-based virtual screening system that returns a set of novel bioisosteres with or without knowledge of the target’s protein structure. FieldScreen compares the Fields surrounding your lead in a given 3D conformation against a database of Field pharmacophores created from several million drug-like compounds.
Molecules that can present the same Field pattern, whether or not they have a similar 2D structure, will be active against the same biological target. FieldScreen helps Computational Chemists to:
Increase the diversity of a program’s leads and backups
Find novel bioisosteres to expand into new areas of chemistry
Identify potential bioisosteres to external drugs or in-licensing candidates already in your corporate collection
Improve the lead-like properties of hits
Design diverse libraries of compounds for synthesis and/or biological screening
FieldScreen is excellent for replacing peptide with non-peptide and steroid with non-steroid leads, as well as finding novel leads from screening hits or known drug structures. As well as our large compound library, you can add your in-house compound collections to FieldScreen using its Database Generator tool.
The Field based chemistry revolution
Changing the way we think and work with small molecules
Experience the advantage of Field based chemistry!
