抗体名称：IRAK1抗体;Anti-IRAK1抗体
背景资料： Interleukin-1 receptor-associated kinases (IRAKs) are a unique family of death domain containing protein kinases that play a key role in initiating innate immune response against foreign pathogens. They are involved in Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling pathways. IRAK1 is the first member of this kinase family. Upon ligand binding to TLR/IL-1R, IRAK1 is recruited by MYD88 to the receptor-signaling complex, the association leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Hyper-phosphorylated IRAK1 then disengages from the receptor complex, and forms a cytosolic IRAK1-TRAF6 complex. TRAF6 then interacts with TAK and TAB, resulting in eventual activation of the NF-κB and MAPK pathways. Phosphorylated IRAK1 also undergoes ubiquitin-mediated degradation or sumoylation, which results in nuclear translocation and transcriptional activation of inflammatory target genes. (PMID: ; 12620219)
浓 度： 1mg/1ml
规格：50μg、100μg、150μg 、200μg
宿主：兔源、鼠源、其他
克隆：单克隆、多克隆
适用：人、小鼠、大鼠、鸡、狗、猪、马、羊、猴、牛等
抗体类型：一抗
性 状： 冻干粉或液々体
保存建议：提供的IRAK1抗体;Anti-IRAK1抗体产品为液体或冻干粉，溶解于1x PBS缓冲液(pH 7.3)中。请将◤其置于 -20°C或更低温度下保存，我们建议分装以避免反复冻融。
产品应用 ：免疫组织化学, 异硫氰酸荧光素 , 蛋白质印迹, 石蜡切片的免疫【组化技术，ELISA 等。
同时提供多种荧光素标记IRAK1抗体;Anti-IRAK1抗体，包括以下荧光素：Alexa Fluor 350 Alexa Fluor 488 Alexa Fluor 555 Alexa Fluor 647 AP APC Biotin Cy3 Cy5 Cy5.5 Cy7 FITC Gold HRP PE PE-Cy3 PE-CY5 PE-CY5.5 PE-CY7 RBITC ，欢迎来电洽谈。
IRAK1抗体;Anti-IRAK1抗体相关抗体：
SERPINB11丝氨酸√蛋白酶抑制剂B11抗体 Rabbit polyclonal to Cadherin 8 microlitres Primary antibodies Standard
SERPINB10丝氨酸蛋白酶抑制剂B10抗体 Rabbit polyclonal to Cadherin 8 micrograms Primary antibodies Standard
SERPINB1丝氨酸蛋白酶抑制剂B1抗体 Rabbit polyclonal to Cadherin 7 - N-terminal micrograms Primary antibodies Standard
SERPINA12/Vaspin内脏脂肪组织源性丝氨酸蛋白酶抑制蛋白抗体 Rabbit polyclonal to Cadherin 7 micrograms Primary antibodies Standard
SERPIN A11丝氨酸蛋白酶抑制剂A11抗体 Rabbit polyclonal to Cadherin 7 micrograms Primary antibodies Standard
SERINC3丝氨酸合并蛋白3抗体（肿瘤差异表达蛋白） Rabbit polyclonal to Cadherin 16 microlitres Primary antibodies Standard
Serca2/SERCA2 ATPase肌浆/内质网钙ATP酶2抗体 Rabbit polyclonal to Cadherin 16 micrograms Primary antibodies Standard
SERCA1 ATPase肌浆/内质网钙ATP酶1抗体 Rabbit polyclonal to cadherin 10 - Aminoterminal end microlitres Primary antibodies Standard
SERBP1纤溶酶原激活物抑制剂1 RNA结合蛋白抗体 Rabbit polyclonal to CAD microlitres Primary antibodies Standard
Septin 8细胞分化蛋白SEPT8抗体 Rabbit polyclonal to CAD microlitres Primary antibodies Standard
Septin 3神经元特异性蛋白3抗体 Rabbit polyclonal to CAD microlitres Primary antibodies Standard
IRAK1抗体;Anti-IRAK1抗体知识拓展》》》抗原修复的临床应用：
上个世纪九十年代早期，随着抗原修复技术的发展，免疫组化应用在常规处理火胶棉包埋的人类颞骨上，从分子水平上了解人类发病机理和病理生理学，创立了一个新的领域[13]。使用抗原修复方法，在常规处理石蜡切片上评估IC5和ID15单克隆抗体的免疫组化染色[14]。 Charalambous. C等人 [15]强烈推荐MW-AR-IHC方法检测R-S细胞的CD30。抗原修复技术成功应用于原位杂交[16]。利用加热抗原修复-免疫组化技术，在福尔马林固定、石蜡组织切片上用抗毒素#4350检测nestin[17]。采用抗复技术，在人类上皮、神经、神经内分泌组织中免疫组化定位DCC蛋白[18]。抗原修复-免疫组化已广泛应用于◥临床的研究中。
