抗体名称:INPP5E抗体;Anti-INPP5E抗体
背景资料: INPP5E(72 kDa inositol polyphosphate 5-phosphatase) converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2.In mouse, highest protein expression was in brain, heart, and testis, with lower expression in thymus and lung, and very little expression in kidney, spleen, and liver(PMID:10764818). Defects in INPP5E are the cause of Joubert syndrome type 1 (JBTS1) and mental retardation-truncal obesity-retinal dystrophy-micropenis (MORMS)(PMID:19668215). It has 2 isoforms with the molecular mass of 66 kDa and 70 kDa. This antibody is specific to INPP5E.
浓 度: 1mg/1ml
规格:50μg、100μg、150μg 、200μg
宿主:兔源、鼠源、其他
克隆:单克隆、多克隆
适用:人、小鼠、大鼠、鸡、狗、猪、马、羊、猴、牛等
抗体类型:一抗
性 状: 冻干粉或液体
保存建议:提供的INPP5E抗体;Anti-INPP5E抗体产品为液体或冻干粉,溶解于1x PBS缓冲液(pH 7.3)中。请将其置于 -20°C或更低温度下保存,我们建议分装以避免反复冻融。
产品应用 :免疫组织▓化学, 异硫氰酸荧光素 , 蛋白质印迹, 石蜡切片的免疫组化技术,ELISA 等。
同时提供多种荧光素标记INPP5E抗体;Anti-INPP5E抗体,包括〓以下荧光素:Alexa Fluor 350 Alexa Fluor 488 Alexa Fluor 555 Alexa Fluor 647 AP APC Biotin Cy3 Cy5 Cy5.5 Cy7 FITC Gold HRP PE PE-Cy3 PE-CY5 PE-CY5.5 PE-CY7 RBITC ,欢迎来电洽谈。
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INPP5E抗体;Anti-INPP5E抗体知识拓展》》》抗原修复的临床应用:
上个世纪九十年代早期,随着抗原修复技术的发展,免疫组化应用在常规处理火胶棉包埋的人类颞骨上,从分子水平上了解人类发病机理和病理生理学,创立了一个新的领域[13]。使用抗原修复方法,在常规处理石蜡切片上评估IC5和ID15单克隆抗体的免疫组化染色[14]。 Charalambous. C等人 [15]强烈推荐MW-AR-IHC方法检测R-S细胞的CD30。抗原修复技术成功应用于原位杂交[16]。利用加热抗原修复-免疫组化技术,在福尔马林固定、石蜡组织切片上用抗毒素#4350检测nestin[17]。采用抗复技术,在人类上皮、神经、神经内分泌组织中免Ψ 疫组化定位DCC蛋白[18]。抗原修复-免疫组化已广泛应用于临床的研究中。