抗体名称：NOTCH1抗体,Anti-NOTCH1抗体
背景资料： NOTCH1, also named as TAN1, belongs to the NOTCH family. NOTCH1 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. NOTCH1 affects the implementation of differentiation, proliferation and apoptotic programs. It may be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. NOTCH1 is involved in the maturation of both CD4+ and CD8+ cells in the thymus. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia. Defects in NOTCH1 are a cause of bicuspid aortic valve (BAV).
Notch is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane. The antibody is specific to NOTCH1. It can recognize the full length NOTCH1(270kd) and all the three cleaved NOTCH1 forms. 浓 度： 1mg/1ml
规格：50μg、100μg、150μg 、200μg
宿主：兔源、鼠源、其他
克隆：单克隆、多克隆
适用：人、小鼠、大鼠、鸡、狗、猪、马、羊、猴、牛等
抗体类型：一抗
性 状： 冻〗干粉或液体
保存建议：提供的NOTCH1抗体,Anti-NOTCH1抗体产品为液体或冻干粉，溶解于1x PBS缓冲液(pH 7.3)中。请将其置于♂ -20°C或更低温度下保存，我们建议分装以避免→反复冻融。
产品应用 ：免疫组织▂化学, 异硫氰酸荧光素▃ , 蛋白】质印迹, 石蜡切片的免疫组化技术，ELISA 等。
同时提供『多种荧光素标记的NOTCH1抗体,Anti-NOTCH1抗体，包括以下荧光素：Alexa Fluor 350 Alexa Fluor 488 Alexa Fluor 555 Alexa Fluor 647 AP APC Biotin Cy3 Cy5 Cy5.5 Cy7 FITC Gold HRP PE PE-Cy3 PE-CY5 PE-CY5.5 PE-CY7 RBITC ，欢迎来电洽谈。
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NOTCH1抗体,Anti-NOTCH1抗体知识拓展》》》抗原修复的临床应用：
上个世纪九十年代早期，随着抗原修㊣复技术的发展，免疫组化应用在常规处理火胶棉包埋△的人类颞骨上，从分子水平上了解人类发病机理和病⊙理生理学，创立了一个新的领域[13]。使用抗原修复∩方法，在常规处理石蜡切片上评估IC5和ID15单克♀隆抗体的免疫组化染色[14]。 Charalambous. C等人 [15]强烈推荐MW-AR-IHC方法检测R-S细胞的CD30。抗原修复技术☆成功应用于原位杂交[16]。利用加热抗原修复-免疫组化技术，在福尔马林固定、石蜡组织切片上用抗毒≡素#4350检测nestin[17]。采用抗复技术，在人类上皮、神经、神经内分泌组织中免疫组化定√位DCC蛋白[18]。抗原修复-免疫组化已广泛应用于临床的研究中。
